Categories
Cardiovascular
Diagnostics
Endocrinology
Health Insurance
Medical Devices
Mental Health
Nutrition
Oncology
Public Health
Sexual Health
Buy dildos and sex toys.
Popular Articles

Risk Of HIV Transmission Heightened By Risky Sexual Behavior Among Male Clients Of Tijuana Sex Workers
A study by a bi-national team of global health researchers at the University of California, San Diego School of Medicine, examining HIV infection among male clients of female sex workers in Tijuana, has found that over half of male clients had recently had unprotected sex. They also reported a high prevalence of drug use.
buy viagra
Boston Arm Of Multi-City Study To Focus On Sexual Health, HIV Risk Among Black Gay, Bisexual Men
Boston-based Fenway Health and the Multicultural AIDS Coalition "have launched the recruitment phase of a new study aimed at learning more about the sexual health of black gay and bi[sexual] men and finding effective strategies for HIV prevention within the black gay community," Bay Windows reports. The study, called Project Saving Ourselves (SOS), is seeking to recruit up to 400 participants in Boston, and also is collecting data on black gay and bisexual men in New York, Washington, D.C., Atlanta, Los Angeles and San Francisco. Ben Perkins, Project SOS director at the Fenway Institute of Fenway Health"s research division, said, "This is pretty new. In terms of the scale, there hasn"t been anything quite like it." Perkins said there are several questions researchers hope to answer about black gay and bisexual male health and HIV prevention, but the goal is to determine what factors put them at risk for HIV and help promote better health and safe behavior (Jacobs, 7/15).
News of the day
Afinitor(R) Phase II Data Show Positive Results For Patients With Multiple Types Of Lymphoma, Leading To Phase III Trial
New data show that Afinitor(R) (everolimus) tablets significantly shrunk tumors in 33% of patients with relapsed non-Hodgkin"s lymphoma (NHL) and Hodgkin"s disease(1). Based on results from this study and other early-stage research, Novartis has initiated a Phase III trial in the most common NHL, diffuse large B-cell lymphoma (DLBCL).
Nutrition

A Novel Communication Role For CYP17A1 In The Progression Of Castration-Resistant Prostate Cancer

UroToday.com - This publication describes our unique finding that the steroidogenic enzyme CYP17A1 is present in prostate derived exosomes, isolated from human serum. We also describe CYP17A1 expression in human prostate tissues during castration resistant progression of cancer and identify a subcellular pattern of distribution for CYP17A1 consistent with a secretory protein in human prostate tissues, similar to that of PSA. Amongst the numerous proteins shown to be present in prostasomes we have found this key steroidogenic enzyme involved in testosterone synthesis from cholesterol. CYP17A1 is currently a target of investigational agents such as Abiraterone, which is under investigation for the treatment of advanced castration resistant disease. We postulate that this phenomenon is a cellular response triggered by upregulation of processes required for the cell to undergo cholesterol mediated steroid synthesis to testosterone and DHT within prostate tumour cells and is an adaptive resistance mechanism to depletion of androgens. Despite our inability to demonstrate metabolic enzyme activity in exosome isolates, we believe that CYP17A1 presence in the serum and its elevation in cancer patients compared with healthy controls suggests that it may be a novel diagnostic biomarker. Beyond its potential as a biomarker we propose that CYP17A1 could be playing a communication role in castrate resistant cancer development. In the absence of a supply of testicular androgens, when mechanisms involved in de novo androgen synthesis have been shown to be activated1, exosomal "life-rafts" are released from the cell, loaded with "adaptive survival messages" for other cells to host and potentially assimilate in order to enhance chances of survival. This hypothesis works on the basis that elevated cholesterol levels are observed in cancer cells during castration resistant development, which in turn has been shown to regulate an increase in the extrusion of prostate derived exosomes into the cancer microenvironment2, triggers the release of these "exosomal "life rafts". References: 1. Locke J, Guns ES, Lubik A, Adomat H, Hendy S, Wood C, Gleave ME, Nelson CC: De Novo Synthesis of Androgens as a Potential Mechanism behind Androgen-Independent Prostate Cancer Progression. Cancer Res. 2008 Aug 1;68(15):6407-15 2. Llorente A, van Deurs, B and Sandvig, K: Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. European Journal of Cell Biology 86 (2007) 405-415 Manuscript: Locke J, Fazli L, Adomat H, Smyl J, Weins K, Barr S, Lubik A, Hales B, Nelson CC, Gleave M and Tomlinson Guns ES: CYP17A1 is elevated in the serum of prostate cancer patients as compared to healthy controls. Prostate Mar 2009 [EPub ahead of print] Written by Emma Tomlinson Guns, PhD as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


Add your comment:
Name:
Site address: http://
Your message:
Enter today\\\\'s date, 2 digits
(spam protection):

© Copyright 2009