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Similar Outcomes In Babies Born Following ICSI Or IVF
Analysis of the longest running ICSI programme in the United States has found reassuring evidence that babies born from frozen embryos fertilised via ICSI (intracytoplasmic sperm injection) do just as well as those born from frozen embryos fertilised via standard IVF treatment.
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Make Sure Your Baby Is Seeing The Most Important Things In Their World
When should a parent schedule a comprehensive eye assessment for a baby? Clinical research has shown that at 6 months, the average baby has reached a number of critical developmental milestones, making this an appropriate age for the first eye and vision assessment.
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Access Issues Persist For Indians, Rural Americans, Immigrants
Several reports today focus on inadequate health care for certain population groups within the United States.
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A Potential Drug For Liver Carcinoma

Looking for efficient anti-tumor drugs is a hot research area. Chrysin (5,7-dihydroxy flavone), a natural widely-distributed flavonoid, has been reported to have many different biological activities such as anti-oxidant, anti-virus, antidiabetogenic activity and clear anxiolytic effect. However, Chrysin is limited in its clinical application because of its modest absorption in the intestine and rapid in vivo glycosylation. To improve the biological activity of chrysin, a number of its derivatives have been prepared for biological testing. 5-allyl-7-gen-difluoromethylenechrysin (ADFMChR) is one of them. A research team led by Dr. Jian-Guo Cao from China investigate the anti-tumor effect of ADFMChR in vitro. Their study was published on May 14, 2009 in the World Journal of Gastroenterology. In their study, HepG2 cells and L-02 cells were cultured and the inhibitory effect of ADFMChR on their proliferation was measured by MTT assay. The apoptosis of HepG2 cells was determined by flow cytometry using propidium iodide fluorescence staining. The influence of ADFMChR on the proxisome proliferator-activated receptor í³ (PPARí³), NF-íºB, Bcl-2 and Bax protein expression of HepG2 cells were analyzed by Western blotting. They found that ADFMChR significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner, with little effect on growth of L-02 cells. Western blotting analysis revealed that after 24 h of treatment with 3.0, 10.0, 30.0 í¼mol/L ADFMChR, PPARí³ and Bax protein expression increased but Bcl-2 and NF-íºB expression decreased in HepG2 cells; however, pre-incubation with 10.0 í¼mol/L GW9662, a blocker of PPARí³, could efficiently antagonize and weaken the regulatory effect of 3.0, 30.0 í¼mol/L ADFMChR on PPARí³ and NF-íºB protein expression in HepG2 cells. This finding may provide a molecular basis for the clinically observed cancer-preventive effects of ADFMChR and new clues for research about pharmaceutical prevention and cure of human liver carcinoma. Reference: Tan XW, Xia H, Xu JH, Cao JG. Induction of apoptosis in human liver carcinoma HepG2 cell line by 5-allyl-7-gendifluoromethylenechrysin. World J Gastroenterol 2009; 15(18): 2234-2239 http://www.wjgnet.com/1007-9327/15/2234.asp Correspondence to: Dr. Jian-Guo Cao, Laboratory of Medicine Engineering, Medical College, Hunan Normal University, Changsha 410006, Hunan Province, China. Lai-Fu Li World Journal of Gastroenterology


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