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Weakening IP Would Threaten R&D Investment
A proposal to dramatically weaken intellectual property legislation could lead to the loss
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Phase III Data Showed Novartis Investigational Bronchodilator QAB149 Significantly Improved Lung Function In COPD Patients
The Novartis investigational bronchodilator QAB149 (indacaterol) met the primary efficacy endpoints of improved lung function compared to placebo at 12 weeks in three pivotal phase III studies in chronic obstructive pulmonary disease (COPD) patients. In secondary endpoints of these studies, QAB149 demonstrated clinically relevant lung function improvements within five minutes of the first dose, lasting for 24 hours in COPD patients.
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Australia: Face Mask That Kills Swine Flu Readied For Australian Pandemic Fight
With a four-fold increase in swine flu cases within the last week, Filligent, the Australian-led biotech company, is mobilizing stocks of its anti-infective BioMask to help combat the spread of Influenza A (H1N1) across Australia. The BioMask is the first medical face mask to kill the Influenza A virus within seconds of contact while retaining the breathability required by front-line workers and children, who are often the first to fall in a contagious episode. CEO Melissa Mowbray-d"Arbela says. "We"re allocating our res to respond to Australia"s needs. The BioMask was designed specifically for situations like this."
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Carbon Monoxide Prevents Clotting

Researchers led by Drs. James F. George and Anupam Agarwal at the University of Alabama at Birmingham have found that carbon monoxide (CO) can protect against arterial clotting. They report their data in the July 2009 issue of the American Journal of Pathology. Carbon monoxide poisoning is extremely toxic; exposure prevents oxygen delivery to body tissues and is often fatal. However, inflamed or injured tissues upregulate heme oxygenase-1 (HO-1), a protein that both protects cells and produces CO, suggesting that low levels of CO may have protective effects. To determine if HO-1 and CO can protect against arterial clotting, Chen et al examined clotting mechanisms in mice that received arterial transplants. Absence of HO-1 in these mice resulted in significant mortality due to arterial clotting; however, treatment with a CO-releasing molecule both decreased clotting and improved survival. Drs. George, Agarwal, and colleagues conclude that HO-1/CO plays an "important role ò€¦[in] protection against vascular arterial thrombosis in murine aortic allotransplantation." Chen B, Guo L, Fan C, Bolisetty S, Joseph R, Wright MM, Agarwal A, George JF: Carbon Monoxide Rescues Heme Oxygenase-1-deficient Mice from Arterial Thrombosis in Allogeneic Aortic Transplantation. Am J Pathol 2009, 174: 2832-2839 Angela Colmone American Journal of Pathology


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