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Human Term Placenta A New Abundant Of Hematopoietic Cells
Investigators at Children"s Hospital Oakland Research Institute, Oakland, California found a way to obtain large numbers of hematopoietic stem cell from human term placenta. The results, which appear in the July 2009 issue of Experimental Biology and Medicine, describe detailed report on quantification, characterization, engraftment capacity, and most importantly, practical way to obtain hematopoietic stem cells from placenta in numbers that are several-fold higher than could be obtained from cord blood.
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Hemophilia A Mice Benefit From Gene Therapy
Hemophilia A is an inherited bleeding disease caused by a lack of the blood clotting protein Factor VIII. It had been hoped that gene therapy would provide a breakthrough in treatment, but the most common gene therapy approach has had little clinical success. However, a team of researchers, at the University of Minnesota Medical School, Minneapolis, has now developed a new approach to target genes specifically to mouse liver sinusoidal endothelial cells (the cells that are the main of Factor VIII) and used it to provide long-term expression of Factor VIII in hemophilia A mice, markedly reducing their disease. They hope that their data might prove to be a step toward successful human clinical trials in individuals with hemophilia A.
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Mental Health

Cold Blooded Criminals Use Violence Indiscriminately, UK

Psychopaths are more likely to use violence in a cold blooded, calculated way than non-psychopathic violent offenders. This is the finding of a study being presented today, Thursday 25th June 2009, at the British Psychological Society Division of Forensic Psychology Annual Conference at the University of Central Lancashire, Preston. John Cordwell, in association with Queen Mary College, University of London, studied 492 violent offenders with convictions from common assault to GBH and manslaughter. He compared their levels of psychopathy (as measured on the Psychopathy Checklist - Revised) to an analysis of the violence they used in their crimes. John Cordwell said: "Psychopaths tend to be callous, un-empathic, cunning, and frequently lie. We discovered that offenders who scored highly on the measure of psychopathy committed significantly more instrumental violence than the other offenders - they used violence to achieve goals such as obtaining money, sex or drugs, and there could be little or no emotional component to this violence. "These results indicate that highly psychopathic criminals are more likely than non-psychopaths to use violence to get what they want, and could be seen as "cold blooded". However, these highly psychopathic offenders are also no less likely than other offenders to become violent in a reactive and impulsive way as a result of a highly emotional state. This study further asks the question of whether reactivity is a genuine phenomenon of psychopathy or actually a phenomenon of violence itself. The conference is being held at the University of Central Lancashire from the 23rd to 25th July. British Psychological Society


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