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Clinical Study Evaluates Ability Of Drug To Overcome Resistance To Standard Colorectal Cancer Therapy
Roswell Park scientists are investigating a new combination of drugs for colorectal cancer patients who have become intolerant or resistant to standard therapies. Marwan Fakih, MD, Department of Medicine at Roswell Park Cancer Institute will present the results of a phase I clinical study at the American Society of Clinical Oncology (ASCO) 2009 annual meeting, May 29 - June 2, in Orlando, FL.
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Truthfulness Requires No Act Of Will For Honest People, Neuroimaging Suggests
A new study of the cognitive processes involved with honesty suggests that truthfulness depends more on absence of temptation than active resistance to temptation.
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Possible Link Between Vitamin D Deficiency, Alzheimer's Disease And Vascular Dementia
There are several risk factors for the development of Alzheimer"s disease and vascular dementia. Based on an increasing number of studies linking these risk factors with Vitamin D deficiency, an article in the current issue of the Journal of Alzheimer"s Disease (May 2009) by William B. Grant, PhD of the Sunlight, Nutrition, and Health Research Center (SUNARC) suggests that further investigation of possible direct or indirect linkages between Vitamin D and these dementias is needed.
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FDA Requests Labeling Change For Leukotriene Modifiers

The U.S. Food and Drug Administration provided further updated safety information on a class of asthma drugs known as leukotriene modifiers. The FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling) regarding neuropsychiatric events (behavior, mood changes) that have been reported in some persons taking montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo and Zyflo CR). Leukotrienes are chemicals the body releases in response to an inflammatory stimulus, such as when a person breathes in an allergen. Montelukast and zafirlukast are leukotriene receptor antagonists that work by blocking leukotrienes. Zileuton is a leukotriene synthesis inhibitor which works by stopping the formation of certain substances that cause swelling, tightening, and mucus production in the airways. U.S. Food and Drug Administration


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