Categories
Cardiovascular
Diagnostics
Endocrinology
Health Insurance
Medical Devices
Mental Health
Nutrition
Oncology
Public Health
Sexual Health
Popular Articles
Benefits Of Grapefruit

Risk For Premature Birth May Be Heightened By Pre-Pregnancy Depressed Mood
Researchers trying to uncover why premature birth is a growing problem in the United States and one that disproportionately affects black women have found that pre-pregnancy depressive mood appears to be a risk factor in preterm birth among both blacks and whites.
generic viagra online
Lancet Studies Examine Aspects Of Global Health Funding
"Global health funding boosted by private donors has quadrupled since 1990, but the extra money has not always gone to the right countries and diseases, according to a pair of studies released Friday," in the journal Lancet, AFP/Google.com reports (Hood, AFP/Google.com, 6/18).
News of the day
Parent Project Muscular Dystrophy Holds 15th Annual Connect Conference In Atlanta
Patricia A. Furlong, Founding President and CEO of Parent Project Muscular Dystrophy (PPMD), the largest non-profit organization in the United States focused on finding a cure for Duchenne muscular dystrophy (Duchenne), announced that PPMD will be honoring United States Senator Johnny Isakson and the American Football Coaches Association (AFCA) with "Change It Champion" awards at the 2009 Connect Conference in Atlanta, Georgia on Saturday, June 27. Other award recipients include Darius Weems and Logan Smalley from the acclaimed documentary "Darius Goes West."
Medical Devices

Molecular Machinery Related To Stem Cell Fate Revealed By Xie Lab

The Stowers Institute"s Xie Lab has revealed how the BAM protein affects germline stem cell differentiation and how it is involved in regulating the quality of stem cells through intercellular competition. The work was published by PNAS Early Edition. Maintaining the proper balance between stem cell self-renewal and differentiation is critical for normal homeostasis. An imbalance between the two can lead to tissue degeneration and to the development of tumors. It has long been known that the BAM protein is necessary for germline stem cell differentiation, but the specific molecular mechanism underlying BAM function had remained a mystery until now. Examining the fruit fly ovary, the Xie Lab established that BAM controls stem cell differentiation and competition by interfering with the function of the protein translation initiation factor eIF4A. EIF4A and BAM antagonize each other to regulate the balance between self-renewal and differentiation by promoting proper expression of E-cadherin - a molecule crucial to the stem cell"s ability to attach to its microenvironment (its niche). "Our studies contribute to the understanding of stem cell fate control," said Run Shen, Ph.D., Postdoctoral Research Associate in the Xie Lab and lead author on the paper. "Many protein translation initiation factors have been reported to be unregulated in different human cancer tissues, so our study may help to understand how translational initiation factors participate in stem cell misregulation and the development of tumors." "Our studies have established the role of BAM as a protein translational repressor using biochemical and genetic tests," said Ting Xie, Ph.D., Investigator and senior author on the paper. "Translational control is very important in regulating gene expression. Many genes critical for stem cell development in the fruit fly germline are suggested to be translational regulators, but their exact roles have not been carefully studied. The knowledge generated by this work and the tests we have developed give us great advantage in tackling many additional questions." Ting Xie, Ph.D., Investigator, also is a Professor in the Department of Anatomy & Cell Biology at The University of Kansas School of Medicine. Marie Jennings Stowers Institute for Medical Research


Add your comment:
Name:
Site address: http://
Your message:
Enter today\\\\'s date, 2 digits
(spam protection):

© Copyright 2009