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Silenced Genes As A Warning Sign Of Blood Cancer
In many types of cancer, parts of the genetic material of tumor cells are switched off by chemical labels called methyl groups. This kind of methyl labeling ranges among the epigenetic changes that do not change the sequence of DNA building blocks. Such labels are found particularly often in genes which act as important inhibitors of pathogenic cell growth.
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Tips For Older Adults To Combat Heat-Related Illnesses
As we age, our ability to adequately respond to summer heat can become a serious problem. The National Institute on Aging (NIA), part of the National Institutes of Health, has some advice for helping older people avoid heat-related illnesses, known collectively as hyperthermia, during the summer months.
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Analysis: How Will $155 Billion Deal With White House Really Affect Hospitals?
When hospitals agreed to accept a $155 billion pay cut from the federal government to help Washington raise money for reform efforts earlier this month, it was "to the amazement of many," the Economist reports. "How can they justify giving away such a vast sum? There are several explanations, not all of them altruistic. Taken together, they show that the industry"s leaders are bracing themselves for a period of upheaval."
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Particles Held For On-Chip Analysis By Integrated Optical Trap

A new type of optical particle trap can be used to manipulate bacteria, viruses and other particles on a chip as part of an integrated optofluidic platform. The optical trap is the latest innovation from researchers at the Jack Baskin School of Engineering at the University of California, Santa Cruz, who are developing new sensor technology for biomedical analysis and other applications. "Ultimately, it could have applications for rapid detection of bacteria and viruses in hospitals, for cell sorting in research labs, and for process monitoring in chemical engineering," said Holger Schmidt, professor of electrical engineering and director of the W. M. Keck Center for Nanoscale Optofluidics at UCSC. The new technique offers the potential to create a smaller, cheaper version of the sophisticated equipment used to perform fluorescence-activated cell sorting (FACS), Schmidt said. "The capabilities of our optofluidic platform are continuing to grow. We have gone from the detection of single molecules and single viruses to now being able to control the movement of particles," he said. Schmidt"s group has received a $400,000 grant from the National Institutes of Health to explore particle trapping and sorting and other applications of the optofluidics platform. An article describing the optical trap for on-chip particle analysis has been published online by the journal Lab on a Chip. First author Sergei Kuhn was a postdoctoral researcher in Schmidt"s lab and is now at the Max-Born Institute in Berlin. Coauthors include David Deamer and Philip Measor at UCSC and E. J. Lunt, B. S. Phillips, and A. R. Hawkins of Brigham Young University, where the optofluidic chips are fabricated. Optical traps and "optical tweezers" use the momentum carried by the photons in a beam of light to exert forces on microscopic objects, enabling researchers to manipulate objects ranging from biological molecules to living cells. Schmidt"s group developed a new way to perform optical trapping on a chip-based platform. The technique relies on an earlier innovation from Schmidt"s lab: a hollow-core optical waveguide that can direct a beam of light through a liquid-filled channel on a chip. To trap particles, the researchers used two laser beams at opposite ends of a channel. A particle gets trapped at the point where the forces exerted by the two beams are equal, and the particle can be moved by changing the relative power of the two laser beams. "We can also use this like an optical leaf blower to push all the particles in a sample to the same spot and increase the concentration," Schmidt said. "The goal is to control the position and movement of particles through channels on a chip so they can be studied using fluorescence analysis and other optical methods." Tim Stephens University of California - Santa Cruz


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