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Nephrogenic Systemic Fibrosis And Gadolinium-Based Contrast Agents
Even at very high doses, gadolinium-based contrast agents alone are not sufficient to cause nephrogenic systemic fibrosis (NSF) in patients with kidney problems, according to a study performed at the Mayo Clinic Florida, Jacksonville, FL. NSF is a rare and serious syndrome that leads to fibrosis of the skin, joints and even internal organs. Some research indicates NSF is caused by gadolinium-based contrast agents that are commonly used today during MR procedures.
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DoH Confirms First Cases Of NOVEL H1N1 Influenza A On The Island Of Kaua'i, Hawai'i
The Hawai"i State Department of Health (DOH) confirmed 83 additional cases of novel H1N1 Influenza A of swine origin this week. Two of the individuals live on the island of Kaua"i, one individual lives on the island of Maui, two individuals live on the island of Hawai"i, and 78 are O"ahu residents. It is important to note that all of the individuals have recovered or are recovering at home with no complications. The next weekly update will be posted at http://www.hawaii.gov/health on Wednesday, June 17 at 11:00 a.m.
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'Hijacking Mechanism' Of HIV-1' Pinpointed By McGill/JGH Researchers
Researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal"s Jewish General Hospital - along with colleagues at the University of Manitoba and the University of British Columbia - may have found a chink in the armour of the human immunodeficiency virus type 1 (HIV-1), the microorganism which causes AIDS. They have pinpointed the key cellular machinery co-opted by HIV-1 to hijack the human cell for its own benefit. Their study was published in May in the Journal of Biological Chemistry.
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Physical Activity Reduces Prostate Carcinogenesis In A Transgenic Model

UroToday.com - A recent European study demonstrated that 10-year mortality from cardiovascular disease and cancer was decreased in a population of 70 to 90 year olds who adhered to a Mediterranean diet, were physically active, had moderate alcohol consumption and did not smoke. There are also reports suggesting an inverse association between physical activity and risk of prostate cancer (CaP). Yet mechanisms linking lifestyle and longevity are not well investigated. This report in The Prostate investigates an animal model for the association between physical activity and development of CaP. Male C3(1)Tag mice were used in the study. These mice are predisposed to CaP due to the directed expression of SV40 oncogenes to that organ combined with voluntary exercise. Exercise consisted of running on a computer monitored running wheel. Nine mice served as non-running controls and 20 mice were in the running group. The amount of running by each mouse was recorded by the computer and access to the wheel was continuous. In this model, detectable prostate carcinogenesis is usually underway by 20 weeks of age. Histopathology was performed at 20 weeks of age by blinded interpretation. Mice ran for an average of 4.03km/day and at an average speed of 0.72km/hr. There was no difference between the two groups regarding increase in body weight over time. There were no apparent differences in histopathology grading between mice housed in standard cages and those in the running cages. In subgroup analysis, mice that ran >5km/day exhibited a trend for more normal prostate phenotype. Thus the suggestion is that CaP is likely delayed or diminished by increase wheel running in transgenic C3(1)Tag mice, but this observation was limited to the mice who run >5km/day. The study is novel and may require remodeling to further substantiate the hypothesis. Esser KA, Harpole CE, Prins GS, Diamond AM Prostate. 2009 Jun 1. (Epub ahead of print) 10.1002/pros.20987 Written by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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