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New Biosensor Detects Extremely Low Bacteria Concentrations Quickly, Easily And Reliably
Bacterial diseases are usually detected by first enriching samples, then separating, identifying, and counting the bacteria. This type of procedure usually takes at least two days after arrival of the sample in the laboratory. Tests that work faster, in the field, and without complex sample preparation, whilst being precise and error-free, are thus high on the wish list. A Spanish research team headed by Jordi Riu and F. Xavier Rius at the University Rovira i Virgili in Tarragona has now developed a new technique to make this wish come true. With a novel biosensor, they have been able to detect extremely low concentrations of the typhus-inducing Salmonella typhi. As reported in the journal Angewandte Chemie, their new method is based on electrochemical measurements by means of carbon nanotubes equipped with aptamers as bacteria-specific binding sites. If bacteria bind to the aptamers, the researchers detect a change in electrical voltage.
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Boston To Unveil New Teen Sex Awareness Program After Spike In STI Cases
Boston"s health agency on Tuesday is scheduled to launch a safer-sex campaign that reaches out to teenagers through Web sites such as Facebook and YouTube, the Boston Globe reports. The campaign was created in response to rising rates of sexually transmitted infections among young people in the city, according to the Globe. The $100,000 campaign originally was intended to address communicable diseases in general. However, experts noticed the increase in STI cases among teenagers and decided to spend all the funding on the campaign targeting STIs.The increase in chlamydia cases in particular demonstrates the "scope of the challenge," as 1,383 Boston youths between ages 15 and 19 were diagnosed with the STI in 2007, a 70% increase since 1999, the Globe reports. The overall rate of chlamydia in Boston is more than twice the national average, and chlamydia and gonorrhea are more common among adolescents than any other age group in Boston. According to the Globe, a city study released in early 2009 found that 56% of Boston public high school students have had sex, and 24% of the sexually active students said they have had more than six partners.For the campaign, "teenagers will do much of the talking" in a video that offers information on STIs, the Globe reports. The video will air on cable channels that are popular with teenagers, such as MTV, FX and BET. It shows teenagers in a classroom receiving information on safer sex, including details about condoms and STI screening. The video does not discuss sexual abstinence.The campaign also includes advertisements on mass transit and the radio, as well as a team of teenagers that will travel around Boston performing street theater addressing the risks associated with STIs. Through the social networking Web site Facebook, teenagers can post questions anonymously regarding sexual health that will be answered by a disease specialist. Videos related to the campaign also will be posted on YouTube.Margaux Joffe, multimedia coordinator at the Public Health Commission, said teenagers "told us, "We don"t want some 40-year-old woman telling us about sex and STIs."" Joffe added that it "makes sense" because a teenager "may not trust the advice of an adult as much as you would someone in your peer group." Mark Schuster, the chief of general pediatrics at Children"s Hospital Boston who was not involved in the design of the campaign, said that using a "multilevel approach" to address the issue is a "great strategy." He added that young people "can be interested and learn from" a sex education curriculum in school, but "they need it in other settings too."Specialists speculate that the rise in STIs may reflect teenagers" casual attitudes about sex and parents" shifting attention to other children"s health concerns, the Globe reports. Experts also have said that the increase in STIs could reflect increased screening efforts by physicians, who have been "pressed for many years to screen much more carefully kids at younger and younger ages," Stephen Boswell, president of Fenway Health, said. The Globe reports that teenagers do not view HIV/AIDS in the same way previous generations have because of advancements in treatment, so preventing the virus "no longer seems quite as important." Experts are concerned that the spread of other STIs could be a forewarning of a rise in HIV/AIDS cases among teenagers. Anita Barry, a top disease specialist at BPHC, said the gonorrhea and chlamydia cases are "our future HIV cases unless we intervene" (Smith, Boston Globe, 8/4).
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RISPERDAL CONSTA (risperidone) Long-Acting Treatment May Improve Health Outcomes And Reduce Hospitalizations In Patients With Schizophrenia

Schizophrenia is one of the most disabling diseases, and frequent relapses and rehospitalization as a result of the disease place enormous burdens on patients, caregivers and society. According to two new studies, the use of RISPERDAL® CONSTA® (risperidone) Long-Acting Treatment (RLAT) may improve clinical and functional outcomes and reduce rates of rehospitalization among patients with schizophrenia. Results of the studies were presented this week at a major medical meeting. In an analysis of two prospective, observational two-year studies conducted in the U.S. and three other countries, RISPERDAL® CONSTA® consistently and significantly improved clinical and functional outcomes for patients with schizophrenia. Data were collected at baseline and at three-month intervals up to 24 months, and included the Clinical Global Impression of Illness Severity (CGI-S), which measures clinical effectiveness outcomes, the Global Assessment of Functioning (GAF), and healthcare re utilization. Patients were enrolled in the U.S. (N=532), Spain (N=1345), Australia (N=784) and Belgium (N=408). Across countries, patients treated with RISPERDAL® CONSTA® experienced significant improvements in both outcome measurements compared with baseline scores (p7% of baseline body weight) was 6% placebo versus 9% RISPERDAL® CONSTA®. Maintenance Treatment: Patients should be periodically reassessed to determine the need for continued treatment. Commonly Observed Adverse Reactions for RISPERDAL® CONSTA®: The most common adverse reactions in clinical trials in patients with schizophrenia (ò‰¥5%) were headache, Parkinsonism, dizziness, akathisia, fatigue, constipation, dyspepsia, sedation, weight increase, pain in extremities, and dry mouth. The most common adverse reactions in clinical trials in patients with bipolar disorder trials were weight increase (5% in monotherapy trial) and tremor and parkinsonism (ò‰¥10% in adjunctive therapy trial). Lesley Fishman Johnson & Johnson


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