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Data Shows Incisionless Procedure Reverses Weight Gain
Patients who have regained weight after gastric bypass surgery now have access to an incisionless procedure that appears highly effective at reversing weight gain, according to data presented at the annual meeting of the American Society of Metabolic and Bariatric Surgeons. Santiago Horgan, MD, professor of surgery and director of the Center for the Treatment of Obesity at UC San Diego, presented six-month outcomes from a national registry of 116 patients who underwent the procedure, known as ROSE (Restorative Obesity Surgery, Endolumenal).
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Baxter To Acquire Continuous Renal Replacement Therapy Business From Edwards Lifesciences
Baxter International Inc. (NYSE:BAX) announced today a definitive agreement with Edwards Lifesciences Corporation (NYSE:EW) under which Baxter will acquire certain assets related to Edwards" hemofiltration product line, also known as Continuous Renal Replacement Therapy (CRRT). The transaction is expected to close in the third quarter of 2009, pending regulatory approvals.
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Counterfeit Antimalarial Drug Discovered In Ghana
Quantities of a prescription medication used throughout the world for treating malaria have been identified as lacking any active ingredient and presumably counterfeit. These are being removed from the market in Ghana, where they were discovered recently and confirmed as fake last Friday. The discovery was made by a vigilant citizen who contacted the Medicines Quality Monitoring program set up by the U.S. Agency for International Development (USAID)-supported Drug Quality and Information (DQI) Program, implemented by the U.S. Pharmacopeial (USP) Convention. USP is a nonprofit scientific organization that develops globally recognized standards for the quality of medicines. Through the DQI Program, USP works in developing countries to help verify, assure and improve the quality of medicines intended to treat life-threatening neglected diseases such as malaria, HIV/AIDS and tuberculosis, as well as advance the appropriate use of these medicines.
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The Importance Of Preventing Congestion In Heart Failure

Preventing vascular congestion is an important mediator in heart failure, reports a study in the June issue of the Journal of Cardiac Failure, published by Elsevier. The authors previously demonstrated that venous endothelium is a key regulator of central blood volume, organ perfusion and hemostasis in heart failure (HF). The present study demonstrates that in venous endothelium, inflammatory/oxidative and hemostatic programs were significantly activated in HF dogs compared to normal dogs. In normal dogs, fluid loading significantly activated these same programs to levels that approached those seen in dogs with HF. These findings suggest that biomechanical stress (i.e. vascular stretch) may be an important mediator of these endothelial responses, and highlight the importance of preventing congestion. Further investigation is needed to clarify whether the venous endothelial phenotype in unique individuals may ultimately allow us to track the vascular impact of subsequent environmental (i.e. biomechanical and biochemical) stressors, as well as the potential response to therapeutic interventions. "This important study is consistent with a growing literature, indicating that congestion itself may mediate many of the physiological abnormalities in heart failure, such as vascular dysfunction, inflammation, renal dysfunction and hypercoagulability," commented Barry M. Massie, M.D., Editor-in-Chief of the Journal of Cardiac Failure. Notes: The study, "Activation of Endothelial Cells in Conduit Veins of Dogs with Heart Failure and Veins of Normal Dogs Following Vascular Stretch by Acute Volume Loading," authored by Paolo C. Colombo, Sharad Rastogi, Duygu Onat, Valerio Zacē , Ramesh C. Gupta, Ulrich P. Jorde, and Hani C. Sabbah (DOI: 10.1016/j.cardfail.2008.12.006) was supported by a research grant from the National Heart, Lung and Blood Institute. It appears in the Journal of Cardiac Failure, Volume 15, Issue 5 (June 2009) published by Elsevier.com Maureen Hunter Elsevier


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