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UCLA Study Discovers Enzyme That Controls 'Bad' Cholesterol
BACKGROUND: Low-density lipoprotein (LDL) is the so-called "bad cholesterol" often linked to medical problems like heart disease and clogged arteries. Cells in the liver produce a specific receptor that sticks to LDL and removes it from the blood, lowering cholesterol levels. Statin drugs also reduce LDL cholesterol levels by boosting cells" production of the receptor.
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Signs Of Heart Damage Evident In Overweight Male Teens With Normal Blood Pressures
Even while their blood pressures are still normal, overweight male teens may have elevated levels of a hormone known to increase pressures as well as early signs of heart damage, researchers say.
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Boxers Holyfield, Retta To Participate In HIV/AIDS Charity Fight In Ethiopia
Boxer Evander Holyfield will fight Sammy Retta on July 26 in Ethiopia in an effort to raise money for HIV/AIDS organizations, Reuters India reports. Event organizers hope to raise between $5 million and $10 million from the fight. "I continue to strive to be the very best, but what got me to come here is" HIV/AIDS, Holyfield said, adding, "If we don"t find a cure to this, we"ll be extinct." According to Everton Boland -- CEO of Golden Globe, which is promoting the fight -- a significant portion of money raised will go directly to organizations addressing HIV/AIDS. Organizers said that a group established by African first ladies is the only recipient selected to date but they are considering others (Malone, Reuters India, 5/20).
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Metabolic Disease Drug Discovery Conference: Monday September 21, 2009

on both Clinical and Business Fronts 3:00 Shaping Business Development Through Collaboration Ventures -- Identifying what are the requirements to establish early stage research collaborations -- Extending knowledge gathering beyond existing in-house capabilities -- Expanding the value of a partnership beyond a single deal -- Outsourcing lead finding and early development to partnering companies Dr. Dennis Kim, SVP, Metabolic Diseases, Orexigen Therapeutics Inc 3:45 Scientific Licensing Strategy & Process: Focus on Metabolic Disease Interests -- Outlining Merck"s scientific licensing strategy and review process -- Providing a review of the partnering process, including initiation and negotiation processes -- Identifying what Merck looks for in a potential therapeutic candidate -- Discussing specific licensing priorities for the metabolic diseases area Dr. Lauren Shearman, Associate Director, Scientific Liaison External Scientific Affairs, Merck 4:30 End of Conference IDGA

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